Endocrine Abstracts

BackgroundChronic hypoparathyroidism (hypoPT) predisposes patients to comorbidities such as cardiovascular/cerebrovascular disease, infection, mental illness, and renal impairment often associated with an increased burden to healthcare systems. Suboptimal disease control is common with standard therapy. The objective of this study was to quantify and assess differences in the clinical and economic burden on secondary care among patients with post-surgica...

Background: Treatment of subclinical hypothyroidism (ScH) when TSH is between the upper reference value and 7mU/L, especially in patients younger than 65 years is controversial.Objectives: To compare the risk factors for atherosclerosis and echocardiographic parameters in patients with ScH1 (4, 2≤TSH≤7mU/L) to euthyroid subjects and patients with ScH2 (TSH>7mU/L).Material and Methods: Prospectively 54 consecutive pa...

Introduction: Pheochromocytoma is a rare cause of hypertension in pregnancy. Its prevalence ranges from 0.2% to 0.002% of cases of hypertension in pregnancy. Early diagnosis and appropriate management can reduce mortality and morbidity. Were report a case of pheochromocytoma diagnosed during pregnancy.Observation: 34-year-old diabetic patient, 29 weeks pregnant. Admitted for hypertensive peaks up to 170 mmHg of systolic, initially mistaken for pre-eclamp...

Aims: Identifying the left ventricular systolic disfunction in obesity is crucial, due to its ability to predict cardiovascular morbidity. LV systolic function is traditionally assessed with the volumetric parameter LV ejection fraction (LVEF). However, normal values for LVEF in all categories of obesity are published in the literature. Furthermore, guidelines for the biomarkers of heart failure, NT-proBNP and BNP, in the obese population remain unclear. Given the restricted B...

Introduction: Sheehan Syndrome can be determined as partial or complete hypopituitarism occurring after massive postpartum uterine hemorrhage leading to pituitary infarction. The first symptom classically described is the absence of milk flow. It is a rare and lethal condition, especially in underprivileged countries around the world. The resulting hypothyroidism is often diagnosed late, involving long-term complications. The aim of this study is to determine the prevalence of...

Introduction: Silent somatotroph pituitary adenomas are defined as pituitary adenomas with positive immunostaining for GH without signs of clinical or biochemical acromegaly. Silent somatotroph adenomas are rare and diagnosis is made post-operatively. Almost two-thirds are mixed GH-prolactin tumors. We report the case of a non-functioning macroadenoma coexpressing prolactin and GH.Observation: A 37-year-old man presented with headache and progressive vis...

The relationship between the level of genetic variation in CYP17, PSA genes and prostate cancer has been extensively studied but the results are still unclear. A 450c17a (CYP17) polymorphism A1/A2 was described to be significantly associated to prostate cancer. A SNP in the promotor PSA gene is an A to G substitution at position −158 (G158A) was proposed to interact differently with AR, thereby modifying the expression pattern and occurrence of prostate cancer.<p cla...

Objective: Acromegaly is associated with increased cardiovascular morbidity and mortality. But the data about the evaluation of coagulation and fibrinolysis in acromegalic patients is very limited and to our knowledge, platelet function analysis has never been investigated. So we aimed to investigate the levels of protein C, protein S, fibrinogen, antithrombin 3, and platelet function analysis in patients with acromegaly.Methods: Thirty-nine patients wit...

Idiopathic granulomatous hypophysitis is a very rare inflammatory disease of the pituitary gland. Primary hypophysitis represents a difficult diagnostic challenge because it can imitate pituitary adenomas clinically and radiologically. The diagnosis is usually made histologically by hypophysectomy. We herein present a rare case of idiopathic granulomatous hypopysitis diagnosed primarily by pituitary biopsy.Case: A 50-year-old female patient presented wit...

Neuroendocrine tumours (NETs) of unknown primary (UP-NETs) represent up to 22% of NETs. Primary site identification enables patients to access appropriate treatment but is not always possible by immunohistochemistry or imaging. Given the epigenetic dysregulation of NETs, we aimed to use methylation array data to determine UP-NET tissue-of-origin. DNA from formalin-fixed paraffin embedded tissue from 76 pancreatic NET (PanNETs) (54 training and 22 validation samples) and 53 sma...